In healthy pancreatic islets glucose-stimulated changes in intracellular calcium ([Ca2+]i) provide a reasonable reflection of the patterns and relative amounts of insulin secretion. nifedipine-sensitive calcium-channel flux. Following 3-to-11mM glucose stimulation all stressors substantially reduced the peak glucose-stimulated [Ca2+]i Hoechst 33342 response (first phase). Thapsigargin and cytokines also substantially impacted aspects of calcium influx and ER… Continue reading In healthy pancreatic islets glucose-stimulated changes in intracellular calcium ([Ca2+]i) provide