Pharmacological activation of group II metabotropic glutamate receptors (mGluR2/3) inhibits cocaine self-administration and reinstatement of drug-seeking behavior suggesting a feasible use of mGluR2/3 agonists in the treatment of cocaine dependence. cocaine-induced reinstatement of drug-seeking behavior likely by attenuating cocaine-induced increases in NAc DA and glutamate via presynaptic mGluR2/3s. microdialysis was used to study the effects… Continue reading Pharmacological activation of group II metabotropic glutamate receptors (mGluR2/3) inhibits cocaine