Supplementary MaterialsSupplementary Number 1. reversible acetylation of proteins catalyzed by histone acetyltransferases (HATs) and histone deacetylases (HDACs) is definitely a major epigenetic regulatory mechanism of gene transcription 1 associated with multiple diseases. While HDAC inhibitors are authorized to treat particular cancers, progress within the development of drug-like HAT inhibitors offers lagged 2. The HAT paralogs… Continue reading Supplementary MaterialsSupplementary Number 1. reversible acetylation of proteins catalyzed by histone