Posttranslational protein modifications can play a significant role in disease pathogenesis; phosphorylation, sumoylation, and acetylation modulate the toxicity of a number of proteotoxic protein. of acetylation decreases mutant AR aggregation. Furthermore, hereditary mutation to inhibit polyQ-expanded AR acetylation of lysines 630/632/633 considerably reduced its aggregation and totally abrogated its toxicity in cell lines and engine… Continue reading Posttranslational protein modifications can play a significant role in disease pathogenesis;