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Proteins kinase B (Akt) kinases are critical transmission transducers mediating insulin

Proteins kinase B (Akt) kinases are critical transmission transducers mediating insulin actions. or Akt2 function. Our data demonstrated that Akt1W80A and Akt2W80A mutants are resistant to MK-2206, dynamically controlled by insulin and in a position to transmission to Akt downstream effectors. Analyses of insulin actions in this mobile system demonstrated that Akt1 and Akt2 are…