Category: Hh Signaling

Supplementary Materialsijms-21-04003-s001. was associated with p38 MAPK activation. Treatment with pergolide affected genes involved with homeostasis particularly, that was corroborated with the activation from the professional regulator of cell energy homeostasis, AMPK-, aswell as decreased degrees of metabolism-related miR-107. Hence, both dexfenfluramine and pergolide could cause VHD through valve metabolic reprogramming and matrix remodeling. mice… Continue reading Supplementary Materialsijms-21-04003-s001

Supplementary MaterialsSupplementary material 41598_2019_45820_MOESM1_ESM. Culture-expanded and freshly-purified medial-condyle MSCs expressed higher levels of several ossification-related genes. Using CD271-staining to identify MSCs, their presence and co-localisation with TRAP-positive chondroclasts was noted in the vascular channels breaching the osteochondral junction in lateral condyles. In medial condyles, MSCs were additionally found in small cavities within the sclerotic plate.… Continue reading Supplementary MaterialsSupplementary material 41598_2019_45820_MOESM1_ESM