Supplementary Materialsmolecules-22-01979-s001. 121.056, 110.707, 60.339; HRMS-ESI ((6b). Attained in 23.6% yield, yellow solid. m.p. 183C184 C. 1H-NMR (400 MHz, DMSO-(ppm): 4.30 (d, 1H, = 12.9 Hz), 4.37 (d, 1H, = 12.9 Hz), 6.83 (d, 1H, = 7.8 Hz), 6.96 (t, 1H, = 7.6 Hz), 7.14C7.40 (m, 5H), 7.47 (s, 1H), 7.66 (d, 1H, = 7.6 Hz), 10.80 (s, 1H, NH); 13C-NMR (150 MHz, DMSO-(ppm): 166.580, 161.998, 160.392, 144.414, 143.975, 133.266, 133.245, 133.083, 131.936, 130.620, 130.567, 124.651, 124.633, 123.054, 122.222, 121.024, 118.763, 118.662, 115.711, 115.567, 110.689, 52.692; HRMS-ESI ((6c). Obtained in 39.1% yield, yellow great. m.p. 186C187 C. 1H-NMR (400 MHz, DMSO-(ppm): 4.25 (d, 1H, = 12.8 Hz), 4.36 (d, 1H, = 12.5 Hz), 6.88 (d, 1H, = 7.6 Hz), 7.01 (t, 1H, = 7.6 Hz), 7.16C7.45 (m, 5H), 7.56 (s, 1H), 7.72 (d, 1H, = 7.4 Hz), 10.87 (s, 1H, NH); 13C-NMR (150 MHz, DMSO-(ppm): 166.775, 166.595, 163.148, 161.529, 161.438, 144.057, 143.941, 143.468, 138.142, 135.404, 134.226, 134.175, 133.327, 132.602, 132.530, 132.277, 130.868, 130.813, 130.783, 127.409, 127.226, 126.967, 123.089, 122.565, 122.437, 120.871, 119.687, 117.735, 117.590, 117.497, 117.355, 115.560, 115.456. 115.422, 115.319, 110.967, 110.935, 59.690, 57.929; HRMS-ESI ((6d). Attained in 25.7% yield, yellow solid. m.p. 193C194 C. 1H-NMR (400 MHz, DMSO-(ppm): 4.21 (d, 1H, = 12.6 Hz), 4.32 (d, 1H, = 12.9 Hz), 6.88 (d, 1H, = 7.8 Hz), 7.00 (t, 1H, = 7.6 Hz), 7.19C7.38 (m, 5H), 7.54 (s, 1H), 7.71 (d, 1H, = 7.6 Hz), 10.86 (s, 1H, NH); 13C-NMR (150 MHz, DMSO-(ppm): 166.235, 165.996, 162.940, 162.828, 161.207, 144.377, 143.747, 143.589, 138.367, 134.651, 132.623, 132.566, 132.390, 132.333, 132.153, 132.100, 131.845, 131.475, 130.926, 127.609, 127.081, 126.113, 122.640, 121.812, 121.703, 120.638, 119.415, 115.430, 115.385, 115.226, 115.124, 114.147, 114.007, 110.313, 58.850, 57.098, 56.608; HRMS-ESI ((6e). Attained in 31.6% yield, yellow solid. m.p. 202C203 C. 1H-NMR (400 MHz , DMSO-(ppm): 4.43 (d, 1H, = 12.6 Hz), 4.54 (d, 1H, = 12.6 Hz), 6.85 (d, 1H, = 7.8 Hz), order LBH589 7.00 (t, 1H, = 7.6 JNK Hz), 7.28C7.48 (m, 5H), 7.55 (s, 1H), 7.69 (d, order LBH589 1H, = 7.8 Hz), 10.79 (s, 1H, NH); 13C-NMR (150 MHz, DMSO-(ppm): 166.113, 143.561, 143.526, 133.967, 133.080, 132.910, 131.566, 129.803, 129.346, 129.000, 126.969, 122.680, 121.802, 120.632, 110.258, 56.057; HRMS-ESI ((6f). Attained in 28.6% yield, yellow solid. m.p. 192C194 C. 1H-NMR (400 MHz, DMSO-(ppm): 4.24 (d, 1H, = 12.6 Hz), 4.35 (d, 1H, = 12.3 Hz), 6.88 (d, 1H, = 7.8 Hz), 7.01 (t, 1H, = 7.6 Hz), 7.28C7.42 (m, 5H), 7.56 (s, 1H), 7.72 (d, 1H, = 7.3 Hz), 10.87 (s, 1H, NH); 13C-NMR (150 MHz, DMSO-(ppm): 166.239, 144.172, 143.636, 133.870, 132.849, 132.550, 131.526, 130.155, 130.084, 129.048, 127.848, 122.680, 121.826, 120.600, 110.323, 59.132; HRMS-ESI ((6g). Attained in 23.8% yield, yellow solid. m.p. 193C195 C. 1H-NMR (400 MHz, DMSO-(ppm): 4.22 (d, 1H, = 12.9 Hz), 4.34 (d, 1H, = 12.6 Hz), 6.88 (d, 1H, = 7.6 Hz), 7.01 (t, 1H, = 7.6 Hz), 7.30C7.46 (m, 5H), 7.52 (s, 1H), 7.71 (d, 1H, = 7.3 Hz), 10.84 (s, 1H, NH); 13C-NMR (150 MHz, DMSO-(ppm): 166.235, 144.302, 143.609, 132.789, 132.463, 132.177, 131.495, 130.376, 128.309, 122.684, 121.818, 120.620, 110.311, 58.852; HRMS-ESI ((6h). Obtained in 50.0% yield, yellow solid. m.p. 198C199 C. 1H-NMR (400 MHz, DMSO-(ppm): 4.46 (d, 1H, = 12.9 Hz), 4.56 (d, 1H, = 12.9 Hz), 6.86 (d, 1H, = 7.8 Hz), 7.00 (t, 1H, = 7.1 Hz), order LBH589 7.25C7.49 (m, 4H), 7.56 (s, 1H), 7.64 (d, 1H, = 7.8 Hz), 7.70 (d, 1H, = 7.6 Hz), 10.78 (s, 1H, NH); 13C-NMR (150 MHz, DMSO-(ppm): 166.083, 143.529, 143.271, 133.056, 132.659, 131.582, 130.720, 129.989, 127.520, 124.781, 122.701, 121.794, 120.638, 110.256, 58.383; HRMS-ESI ((6i). Obtained in 51.7% yield, yellow solid. m.p. 193C194 C. 1H-NMR.