The purpose of the study was to investigate whether the structure-function relationship in glaucomatous and normative eyes is improved by considering photoreceptor layer thickness. receive visual information from photoreceptors (PhRs) and collectively transmit the information to the brain through the optic disc and retinal nerve fiber layer (RNFL). Many studies have investigated the structure-function relationship in glaucoma using optical coherence tomography (OCT), assessing damage to RGCs and the RNFL1C4. It remains controversial whether PhR thickness is important for FK866 enzyme inhibitor the structure-function relationship; recent studies investigating OCT-measured thickness of the PhR layer have failed to show that a decline in this measurement is associated with HDAC10 the advance of glaucoma5C8. These studies investigated the relationship between PhR FK866 enzyme inhibitor thickness and visual field (VF) sensitivity using the 24-2 or 30-2 Humphrey Field Analyzer (HFA, Carl Zeiss Meditec, Dublin, CA) test pattern, however, the macular scan region of OCT corresponds to a much narrower area of the VF9,10. Thus, it may be more appropriate to measure the relationship between macular PhR layer thickness and VF sensitivity using a 10 degrees VF test pattern, rather than the 24-2 or 30-2 HFA test pattern. In our previous report, we investigated the structure-function relationship between OCT measured retinal thicknesses and the central 10 degrees VF; we concluded that it was beneficial to consider the PhRs outer segment layer (OSL) thickness in order to improve FK866 enzyme inhibitor the structure-function relationship11. However, this result was investigated only in eyes with glaucoma and it is unclear whether a similar relationship can be observed in normative eyes. The structure-function relationship is important in normative eyes because it has been reported that there is a significant correlation between the thickness of ganglion cell layer (GCL)+ inner plexiform level (IPL) and VF awareness12. Furthermore, retinal width is reduced in eye with high myopia because of the elongation from the eyes13C16; therefore, additionally it is vital that you FK866 enzyme inhibitor investigate the result of OSL width over the structure-function romantic relationship in extremely myopic eye with and without glaucoma. Within this research we investigate the structure-function romantic relationship in glaucomatous and normative eye with and without high myopia. Structural measurements from OCT had been compared with useful measurements in the HFA 10-2 VF check, and we investigate if the structure-function romantic relationship is normally improved by taking into consideration OSL thickness as well as the thicknesses of RNFL and GCL. Strategies This research was accepted by the study Ethics Committee of Graduate College of Medication and Faculty of Medication at the School of Tokyo, Inouye Eyes Hospital, JR Tokyo General Hiroshima and Medical center Memorial Medical center. Written consent was presented with by patients because of their information to be stored in the hospital database and utilized for study; otherwise, based on the regulations of the Japanese Recommendations for Epidemiologic Study 2008 issued by the Japanese Government, the study protocols did not require that every patient provide written educated consent. Instead the protocol was published in the outpatient medical center to notify participants of the study. This study was performed according to the tenets of the Declaration of Helsinki. Subjects Subjects comprised 615 eyes of 391 subjects, including 100 normative eyes of 53 subjects (26 eyes of 14 subjects were highly myopic and the remaining 74 eyes of 39.