Establishing An HIV clinic in Addis Ababa Ethiopia. appointments were evaluated. The proportion of individuals screened for TB symptoms improved from 22% at baseline to 94% following a treatment (P<0.001). Screening rates improved from 51% to 81% (P<0.001) for physicians and from 3% to 100% (P<0.001) for nurses. Of the 281 individuals with bad TB sign screens and eligible for IPT 4 were prescribed IPT before the intervention compared to 81%(P<0.001) afterward. Conclusions We found a QI treatment significantly improved WHO recommended TB screening rates and IPT administration. Utilizing nurses can help increase TB screening and IPT provision in resource-limited settings. Keywords: Quality Improvement Implementation Science Checklists Task shifting Intro Tuberculosis (TB) is definitely a major global public health problem among people living with HIV (PLHIV).1 HIV increases the progression from latent TB infection (LTBI) to Gefitinib (Iressa) active TB disease.2 The increased disease burden caused by the co-infection of TB and HIV makes it critically important to detect TB among PLHIV; highlighted by reports of high TB related mortality among HIV-infected individuals started on antiretroviral (ART) therapy.3 TB detection via active screening prompts earlier treatment initiation reducing the burden of disease.4 The World Health Business (WHO) has recommended program screening for active TB in all PLHIV.5 Those found to have active TB should be given standard treatment and WHO has recommended that those in whom active TB is excluded should be presumptively given isoniazid preventive therapy (IPT) to prevent progression to active TB disease in high burden resource-limited areas.6 However as of 2011 among the 33.3 million PLHIV it is estimated that only 3.2 million (9.6%) have been screened for TB and only 450 0 of Gefitinib (Iressa) those screened and without active TB were offered IPT.7 In a recent meta-analysis Getahun et al reported that lack of four TB-related symptoms (cough fever night time sweats weight loss) identified PLHIV who have been at extremely low risk for active TB disease (negative predictive value of 97.7%) and could be offered IPT.8 With this study possessing a positive sign display experienced a level of sensitivity of 78.9% and a specificity of 49.6% in settings with 5% prevalence of IL18 antibody TB among PLHIV. Based on these observations the WHO used these screening criteria for active TB case getting among all PLHIV in 2011 and recommended offering IPT in those who screen bad.5 Ethiopia is one of 22 high burden Gefitinib (Iressa) TB countries that account for more than 80% of all global TB cases. In 2011 the estimated TB incidence in Ethiopia was 237 instances per 100 0 people 7 with a higher incidence of 311 instances per 100 0 person-years in some regions.9 Additionally you will find approximately 800 0 PLHIV in the country.10 Shah et al reported a Gefitinib (Iressa) prevalence of Gefitinib (Iressa) active TB of 7% among PLHIV attending an urban HIV clinic in Addis Ababa.4 The Ethiopian Federal government Ministry of Health recommendations recommend TB screening in PLHIV by sign testing sputum smear microscopy and chest radiography.4 However estimations from 2011 suggest that only 21% of PLHIV are screened for TB with 31 0 PLHIV becoming provided with IPT.7 A major concern to improving health in the community is translating evidence-based findings into implementable guidelines. 11 Often medical evidence in support of effective interventions exist; however incorporating them into practice lags years behind.12 With this study we attempted to address this challenge by assessing rates of adherence to the Who also screening criteria for active TB case getting among PLHIV in Addis Ababa Ethiopia. We further evaluated the impact of a cost-effective quality improvement (QI) treatment targeting active TB case getting and provision of IPT among those without active TB disease. STUDY Establishing The study took place in the HIV medical center of Tikur Anbessa Hospital in Addis Ababa Ethiopia. Tikur Anbessa is the teaching hospital for the Addis Ababa University or college (AAU) School of Medicine and is the largest tertiary referral center in Ethiopia. The HIV medical center cares for 3000 HIV-infected individuals yearly. At the medical center HIV-infected individuals are seen by nurses resident physicians and going to physicians. Nurses are.